progenitor – Communicable Diseases Research

SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron Metabolism

SARS-COV-2는 적혈구 전구체를 감염시키고 헤모글로빈과 철 대사를 조절시킨다

Article

Published on 2022-02-182022-09-10
Journal: Stem cell reviews and reports
[Category] COVID19(2023년), MERS, SARS, 변종,

Air-Liquid-Interface Differentiated Human Nose Epithelium: A Robust Primary Tissue Culture Model of SARS-CoV-2 Infection

공기-액체-인터페이스 분화된 인간 코 상피: SARS-CoV-2 감염의 강력한 1차 조직 배양 모델

Article

Published on 2022-01-132022-09-10
Journal: International Journal of Molecular Sciences
[Category] 변종,

[키워드] air–liquid-interface apical surface basal cells caused Cell cell damage ciliated cells communicable communicable disease condition confocal microscopy COVID-19 COVID-19 pandemic Culture culture system delta variant determined by Differentiated cell disease dominant Donor donors Effectiveness feature Human human nasal epithelium human SARS-CoV-2 human tissue human tissues immunofluorescence infected cell infected cells Infection initial inoculated invasive medical countermeasure Medical countermeasures Model nasal nasal epithelium nasal turbinate nose occurred offer organoids portal Prevent progenitor progenitor cells replicate respiratory respiratory tissue robust SARS-CoV-2 SARS-CoV-2 clinical isolates SARS-COV-2 infection Severe acute respiratory syndrome TCID tissue tissue culture unmet need urgency Viral viral entry virus was determined
[DOI] 10.3390/ijms23020835 PMC 바로가기 [Article Type] Article

Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta

베타가 아닌 알파의 SARS-CoV-2 변종에 대한 향상된 적합성

Comparative Study

Published on 2021-12-222022-09-10
Journal: Nature
[Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] ACE2 airway Alpha Alpha variant angiotensin assessment B.1.1.7 B.1.351 Beta Beta variant COVID-19 pandemic cultures driver driving enhanced epithelial experiment Experimental models of disease expressing ferret ferrets fitness greater hamster hamsters high viral replication highlight human ACE2 human Angiotensin-converting enzyme in vitro in vivo mechanism mice nasal overcome progenitor receptor Replication respiratory SARS-CoV-2 SARS-CoV-2 variant similar replication kinetics Spike protein Substitution substitutions Support the spike protein Transmission upper respiratory tract variant variants of concern Viral viral infection virus VoC VOCs
[DOI] 10.1038/s41586-021-04342-0 PMC 바로가기 [Article Type] Comparative Study

Distinct Disease Severity Between Children and Older Adults With Coronavirus Disease 2019 (COVID-19): Impacts of ACE2 Expression, Distribution, and Lung Progenitor Cells

코로나바이러스 질환 2019(COVID-19)가 있는 어린이와 노인 사이의 뚜렷한 질병 심각도: ACE2 발현, 분포 및 폐 전구 세포의 영향

Article

Published on 2021-12-062022-09-12
Journal: Clinical Infectious Diseases: An Official Publicat
[Category] 진단,

[키워드] ACE2 ACE2 expression ACE2 expression and distribution acute respiratory syndrome Adults airway alveolar analyzed angiotensin-converting enzyme 2 biopsies caused cell marker children clinical feature Cohort Combination coronavirus coronavirus disease COVID-19 data sets develop discharged patient disease disease severity distribution ex vivo infection examined expression expression level expression pattern Follow-up Impact Infection Inflammatory response lung lung progenitor cells lung tissue lymphocyte Older older patient older patients Patient patients with COVID-19 patients’ ages. Pneumonia positive cell positive cells progenitor progenitor cell pulmonary tract receptor reduced Region risk factor SARS-CoV-2 SARS-CoV-2 pseudovirus SFTPC single-cell RNA-seq
[DOI] 10.1093/cid/ciaa1911 PMC 바로가기 [Article Type] Article

Evidence for a mouse origin of the SARS-CoV-2 Omicron variant

SARS-CoV-2 오미크론 변이체의 마우스 기원에 대한 증거

Article

Published on 2021-12-012022-09-11
Journal: Journal of genetics and genomics = Yi chuan xue ba
[Category] SARS, 변종,

[키워드] accumulated mutation adaptation B.1.1 lineage base substitutions binding affinity cell entry receptor cellular Divergence Evolution Evolutionary origins Frequency Host hosts Human humans infecting Interaction mammalian mice molecular Molecular spectrum of mutations Mutation occurred omicron outbreak overlapped Patient Point mutation Positive selection progenitor promote Protein binding proximal question raise Receptor-binding domain relative frequency reported SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 variant SARS-CoV-2 variants significantly Spectrum Spike protein Spike protein sequence spike-ACE2 Spike-ACE2 interaction. the SARS-CoV-2 trajectory variant virus virus Virus evolution
[DOI] 10.1016/j.jgg.2021.12.003 PMC 바로가기 [Article Type] Article

Infecting human hematopoietic stem and progenitor cells with SARS-CoV-2

SARS-COV-2로 인간 조혈 줄기 및 전구체 세포를 감염시킨다

Protocol

Published on 2021-10-062022-09-01
Journal: STAR protocols
[Category] MERS, SARS, 진단,

Evolution of Diploid Progenitor Lung Cell Applications: From Optimized Biotechnological Substrates to Potential Active Pharmaceutical Ingredients in Respiratory Tract Regenerative Medicine

Review

Published on 2021-09-242022-10-31
Journal: Cells
[Category] COVID-19, SARS,

[키워드] active pharmaceutical ingredient administration Allogeneic API approach Burn Cell cell banking Cell therapy cell type COVID-19 COVID-19 patient diploid diploid progenitor cells effective effort Evolution FIVE function GMP good manufacturing practice homologous inflammatory lung disease ingredient Local lung lung cell lung cells lung tissue management Medicine MRC-5 cells Patient platform Potential produced progenitor progenitor cell recent regenerative regenerative medicine Research respiratory respiratory tract Safe substrate substrates Symptom syndrome therapeutic therapeutic use therapy tract Vaccine vaccine production vaccine substrate
[DOI] 10.3390/cells10102526 PMC 바로가기 [Article Type] Review

Emerging SARS-CoV-2 Variants of Concern (VOCs): An Impending Global Crisis

Review

Published on 2021-09-232022-10-28
Journal: Biomedicines
[Category] COVID-19,

An Evolutionary Portrait of the Progenitor SARS-CoV-2 and Its Dominant Offshoots in COVID-19 Pandemic

COVID-19 팬데믹에서 SARS-CoV-2의 조상과 그 지배적인 파생물의 진화적 초상화

Fast Track

Published on 2021-08-042022-09-10
Journal: Molecular Biology and Evolution
[Category] SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advancement Analysis Asia China computational method Computational methods coronavirus coronavirus Coronavirus infection Coronavirus infections coronavirus strain COVID-19 dominant Europe Evolution Genetic Genetic variant Genome genomes human infections index case Lineage Mutation North America pandemic Patient Phylogeny Portrait predominant produced progenitor reconstructed reported respiratory reveal SARS-CoV-2 Sequencing severe acute respiratory syndrome Coronavirus spatiotemporal Spread strain the United State Tumor tumor cell tumor cells United States variants web tool
[DOI] 10.1093/molbev/msab118 PMC 바로가기 [Article Type] Fast Track

Sars-CoV-2 Virus Infection May Interfere CD34+ Hematopoietic Stem Cells and Megakaryocyte–Erythroid Progenitors Differentiation Contributing to Platelet Defection towards Insurgence of Thrombocytopenia and Thrombophilia

Hypothesis

Published on 2021-07-302022-10-29
Journal: Microorganisms
[Category] COVID-19,

[키워드] ACE2 adaptive affected Anemia angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) byproduct CD34 CD34+ hematopoietic stem cell (HSCs) Cell cell line cells cellular component Course COVID COVID-19 COVID-19 patient develop differentiation disease entry pathway Ex vivo hematopoietic Hematopoietic stem cell humoral immune cells Infection infections Inflammation Multiple Occurrence Particle Platelets progenitor protein translation RBC Replication risk RNA SARS-CoV-2 STEM target the disease the spike protein thrombocytopenia Thrombophilia thrombosis thrombotic event tissue vaccinated individuals Viral RNA virus Whole blood
[DOI] 10.3390/microorganisms9081632 PMC 바로가기 [Article Type] Hypothesis